- Department / Institute
- Institute for Stroke and Dementia Research
- Subject area
- Stroke and Cardiovascular Disease, Human Genomics, Single-Cell Sequencing
- Project title
- Dissecting the mechanisms underlying atheroprogression with multiomics analyses
- Name of supervisor
- Dr. Marios Georgakis
- Number of open positions
- 1
- Language requirements
- Proficiency in English
- Academic requirements
- MD degree or an MSc degree in epidemiology, biostatistics, public health, data science, biomedical sciences, or related disciplines
- Project time plan
- Full Doctoral Study Model: 36 or 48 months
- Contact
- csc.international@lmu.de
Project description
You will work on a research project with the following objectives:
- Dissect causal immune pathways underlying cerebrovascular disease with the use of downstream analyses in human genomic and other omics data. Applying cutting-edge analyses, such as GWAS, Mendelian randomization, polygenic risk score analyses, colocalization analyses, and genetic correlation in integrated large-scale datasets (genomics, transcriptomics, since-cell sequencing, proteomics, clinical/epidemiological data), the candidate will work on a project aiming to detect promising drug targets for atherosclerosis.
- Follow-up the detected signals in analyses involving human atherosclerotic samples as well as epidemiological studies both in-house and from collaborating biobanks in order to detect mediating plaque phenotypes that could be used as surrogate proxies for studying the atheroprotective effects of immunotherapies.