- Department / Institute
- Institute for Cardiovascular Prevention (IPEK)
- Subject area
- Vascular Biology, microRNAs
- Project title
- 4D live imaging of atherosclerotic lesions
- Name of supervisor
- Prof. Dr. Andreas Schober
- Number of open positions
- 2
- Language requirements
- Proficiency in English
- Academic requirements
- Master's Degree
- Project time plan
- Full Doctoral Study-Model: 48 months
- Contact
- csc.international@lmu.de
Project description
Macrophages and endothelial cells play a key role in forming atherosclerotic plaques. We generated reporter mice expressing a fluorescent protein in these two cell types. We will analyze migration, apoptosis, efferocytosis, and crystal formation of macrophages by confocal imaging. Moreover, we determine the repair of the luminal surface of plaques by endothelial cells. Cell-specific deletion of miRNAs or the miRNA-producing enzyme Dicer in these mice will allow us to study their role in atherosclerotic plaque formation.